Dechra Veterinary Products

Zycortal^® Suspension (desoxycorticosterone pivalate injectable suspension)

For use in: Dogs only

Zycortal Suspension contains desoxycorticosterone pivalate which is a mineralocorticoid hormone indicated for use as replacement therapy for mineralocorticoid deficiency in dogs with primary hypoadrenocorticism (Addison’s disease). Zycortal Suspension was formulated and approved specifically for subcutaneous use.

The desoxycorticosterone pivalate (DOCP) in Zycortal Suspension is a pure mineralocorticoid hormone that regulates electrolytes and water balance, which are impaired in cases of mineralocorticoid deficiency in Addison’s disease. DOCP has limited glucocorticoid activity, allowing the independent dose titration of mineralocorticoid without the risk of inducing marked side effects from glucocorticoid oversupplementation e.g. polyuria, polydipsia, polyphagia and muscle atrophy.

Zycortal Suspension should be used with caution in dogs with congestive heart disease, edema, severe renal disease or primary hepatic failure.

Zycortal Suspension allows you to tailor the dose of mineralocorticoid replacement and the concurrently administered glucocorticoid replacement therapy to the individual dog based on clinical response and normalization of Na⁺ and K⁺ concentrations

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Important Safety Information
As with all drugs, side effects may occur. In field studies and post-approval experience, the most common side effects reported were: polyuria, polydipsia, depression/lethargy, pain on injection, weight gain, inappropriate urination, alopecia, decreased appetite/anorexia, panting, vomiting, diarrhea, shaking/trembling, polyphagia, urinary tract infection, urinary tract incontinence, anaphylaxis, anemia, restlessness and collapse. Death or euthanasia has been associated with some of the adverse events listed above. Zycortal Suspension should be used with caution in dogs with congestive heart disease, edema, severe renal disease or primary hepatic failure. Dogs presenting in Addisonian crisis must be rehydrated with appropriate intravenous therapy before starting treatment with Zycortal Suspension. Refer to the prescribing information for complete details or visit www.dechra-us.com.

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